Virology in Medicine
نویسنده
چکیده
leukemia is not so much the sheer volume of information, but the sense that these three streams of thought are gradually finding certain common mechanistic ground wherein genetics, viruses, and hormones may all play discrete parts in the pathogenesis of these complex disorders. It is toward this goal that editors Gale and Golde vigorously encourage future research directions in hope of achieving a broader understanding of these and other cancers. The second half of this symposium deals with more clinical issues and problems in the treatment of leukemias. A chapter on pharmacology discusses the molecular mechanisms of acquired malignant cell drug resistance to specific agents. It includes Joseph Bertino's work with methotrexate resistance and the experimental antifolate trimetrexate, as well as several clinical trials of varying drug regimens of cytosine arabinoside for use as a CNS prophylactic. The final chapter on therapy provides an excellent summary of the most up-to-date drug regimens, therapeutic tactics, and prognosis in childhood and adult ALL, AML, CML, CLL, and hairy-cell leukemia. Particular emphasis is placed on the encouraging advances made in allogeneic bone marrow transplants and experimental work with autologous marrow treated in vitro with monoclonal antibodies and complement. As exciting as these successes have been, Gale appropriately reminds the reader of how limited the patient population with histocompatible donors is and advocates using our recent fundamental advances in the understanding of the basic biology of leukemias to lead, it is hoped, to the development of more effective and less toxic approaches to the treatment of these diseases. This well-balanced symposium avoids the pitfalls to which many volumes of this size succumb, by neither losing focus of the clinical issues nor attempting to address too large a scientific field. It provides a wide representation of topics in sufficient depth to be of interest to the molecular biologist as well as the student of research oncology and is more than just academic reading for the medical oncologist.
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عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 59 شماره
صفحات -
تاریخ انتشار 1986